7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures
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7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures.
7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory an...
متن کاملSleep and nitric oxide: effects of 7-nitro indazole, inhibitor of brain nitric oxide synthase.
We examined the effect of 7-nitro indazole (7-NI, 2.5-50 mg/kg, i.p.), an inhibitor of central nitric oxide (NO) synthesis, on general behaviour and sleep. The results show that 7-NI induces ptosis, a loss of the righting reflex and decrease of the EEG amplitudes. Furthermore, a duration of slow wave sleep (SWS) and REM sleep decreased, while the latencies of SWS and REM sleep increased. The ef...
متن کامل7-Nitro Indazole, a Neuron-specific Nitric Oxide Synthase Inhibitor, Produces Amnesia in the Chick
7-Nitro i n d a z o l e (7-NI), w h i c h is se lec t ive for t h e n e u r o n a l i s o f o r m of n i t r i c ox ide s y n t h a s e (NOS), was t e s t ed in a pass ive a v o i d a n c e task in t he ch ick . I n j ec t i on o f 50 m g / k g i.p. p r e t r a i n i n g h a d a m n e s i c effects for t he task w h e n t e s t ed 30 m i n , 2 o r 24 h r af ter t r a in ing . I n j ec t i ons p...
متن کامل7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick.
7-Nitro indazole (7-NI), which is selective for the neuronal isoform of nitric oxide synthase (NOS), was tested in a passive avoidance task in the chick. Injection of 50 mg/kg i.p. pretraining had amnesic effects for the task when tested 30 min, 2 or 24 hr after training. Injections post-training had no effect. Because 7-NI does not inhibit the endothelial isoform of NOS, it does not affect blo...
متن کامل7-Nitro indazole, a selective neuronal nitric oxide synthase inhibitor in vivo, impairs spatial learning in the rat.
Nitric oxide (NO) is an intercellular messenger that has been suggested to have a role in learning and memory formation. Previous studies with nonselective NO synthase inhibitors have produced contradictory results in learning experiments. However, these drugs also produced blood pressure changes, as NO is an endothelial-derived relaxing factor. A novel NO synthase inhibitor, 7-nitro indazole (...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 1995
ISSN: 0014-2999
DOI: 10.1016/0014-2999(95)00678-8